Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.200 Therapeutic phenotype CTD_mouse Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics. 28193520 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker phenotype CTD_human Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse. 15996639 2005
Entrez Id: 7200
Gene Symbol: TRH
TRH 		0.300 Therapeutic phenotype CTD_human Antinociceptive properties of thyrotropin releasing hormone in mice: comparison with morphine. 6409194 1983
Entrez Id: 3231
Gene Symbol: HOXD1
HOXD1 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice. 10445233 1999
Entrez Id: 3269
Gene Symbol: HRH1
HRH1 		0.300 Biomarker phenotype CTD_human Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice. 12128009 2002
Entrez Id: 4878
Gene Symbol: NPPA
NPPA 		0.300 Therapeutic phenotype CTD_human The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin. 13679232 2003
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.300 Therapeutic phenotype CTD_human Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats. 27687165 2016
Entrez Id: 10887
Gene Symbol: PROKR1
PROKR1 		0.300 Biomarker phenotype CTD_human Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. 16793879 2006
Entrez Id: 5020
Gene Symbol: OXT
OXT 		0.300 Therapeutic phenotype CTD_human Central oxytocin enhances antinociception in the rat. 17420069 2007
Entrez Id: 5368
Gene Symbol: PNOC
PNOC 		0.300 Therapeutic phenotype CTD_human Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys. 19231294 2009
Entrez Id: 2643
Gene Symbol: GCH1
GCH1 		0.300 Biomarker phenotype CTD_human Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. 19081190 2009
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Therapeutic phenotype CTD_human Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain. 12595749 2003
Entrez Id: 3060
Gene Symbol: HCRT
HCRT 		0.300 Therapeutic phenotype CTD_human Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice. 16202530 2005
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. 20018876 2010
Entrez Id: 7432
Gene Symbol: VIP
VIP 		0.300 Therapeutic phenotype CTD_human Vasoactive intestinal polypeptide induces analgesia and impairs the antinociceptive effect of morphine in mice. 9920454 1998
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin or oxytocin antisera. 6094376 1984